Real Madrid have snatched the 246th El Clasico, after outclassing their archrivals Barcelona 2-1 at the Alfredo Di Stefano stadium.
Los Blancos needed only 13 minutes to take the lead, when French striker Karim Benzema scored with a back-heeled flick, from a cross by Lucas Vazquez.
The hosts made it 2-1 in the 28th minute, when Germany midfielder Toni Kroos found the back of the net with a deflected free-kick.
After missing some big chances, the Catalan giants finally got on the scoresheet when Oscar Mingueza scored with the outside of his foot just before the hour mark.
Barca were so close to scoring a last gasp equalizer, but Ilaix Moriba hit the crossbar, as the hosts survived the nail-biting finish.
With the victory, Zinedine Zidane's side joined Atletico Madrid on 66 points at the summit, although their city rivals can move 3 points ahead, if they win their match over at Real Betis on Sunday.
Barcelona have now moved down to 3rd, a single point behind the leaders.